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TMN355

CAS No. 1186372-20-2

TMN355 ( —— )

Catalog No. M22935 CAS No. 1186372-20-2

TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TMN355
  • Note
    Research use only, not for human use.
  • Brief Description
    TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
  • Description
    TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.?The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    cyclophilin A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1186372-20-2
  • Formula Weight
    380.8
  • Molecular Formula
    C21H14ClFN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)
  • SMILES
    O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.
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