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TMN355
CAS No. 1186372-20-2
TMN355( —— )
Catalog No. M22935 CAS No. 1186372-20-2
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | In Stock |
|
| 10MG | 205 | In Stock |
|
| 25MG | 357 | In Stock |
|
| 50MG | 554 | In Stock |
|
| 100MG | 788 | In Stock |
|
| 500MG | 1602 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTMN355
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NoteResearch use only, not for human use.
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Brief DescriptionTMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
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DescriptionTMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.?The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (pIn VitroTMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation.Western Blot Analysis Cell Line:THP cell lines Concentration:0.5, 1, 2.5, 5 and 10 μM Incubation Time:3, 6 and 9 hours Result:Resulted in 75.9% reduction of cyclophilin A protein expression.In Vivo——Synonyms——PathwayOthersTargetOther TargetsRecptorcyclophilin AResearch Area——Indication——
Chemical Information
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CAS Number1186372-20-2
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Formula Weight380.8
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Molecular FormulaC21H14ClFN2O2
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Purity>98% (HPLC)
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SolubilityDMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)
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SMILESO=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.
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