TMN355

CAS No. 1186372-20-2

TMN355 ( —— )

Catalog No. M22935 CAS No. 1186372-20-2

TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 132 In Stock
10MG 205 In Stock
25MG 357 In Stock
50MG 554 In Stock
100MG 788 In Stock
500MG 1602 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TMN355
  • Note
    Research use only, not for human use.
  • Brief Description
    TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
  • Description
    TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.?The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    cyclophilin A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1186372-20-2
  • Formula Weight
    380.8
  • Molecular Formula
    C21H14ClFN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)
  • SMILES
    O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.
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