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Home - Products - MAPK/ERK Signaling - ERK - CAFESTOL

CAFESTOL

CAS No. 469-83-0

CAFESTOL ( —— )

Catalog No. M20445 CAS No. 469-83-0

CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells.?Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CAFESTOL
  • Note
    Research use only not for human use.
  • Brief Description
    CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells.?Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
  • Description
    CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells.?Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    ERK
  • Recptor
    ERK;COX-2;NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    469-83-0
  • Formula Weight
    316.43
  • Molecular Formula
    C20H28O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mg/mL (15.8 mM)
  • SMILES
    [H][C@]12CC[C@@]34C[C@@H](CC[C@@]3([H])[C@]1(C)CCc1occc21)[C@@](O)(CO)C4
  • Chemical Name
    (3bS5aS7R8R10aR10bS)-7-(Hydroxymethyl)-10b-methyl-3b4567891010a10b1112-dodecahydro-5a8-methanocyclohepta[56]naphtho[21-b]furan-7-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shen T Lee J Lee E et al. Cafestol a Coffee-Specific Diterpene Is a Novel Extracellular Signal-Regulated Kinase Inhibitor with AP-1-Targeted Inhibition of Prostaglandin E2 Production in Lipopolysaccharide-Activated Macrophages[J]. Biological & Pharmaceutical Bulletin 2010 33(1):128-132.
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