Boldine

Research use only, not for human use.

Boldine is a natual product .Boldine displays anti-cancer cytoprotective anti-oxidant and anti-inflammatory activities.

Boldine is a natual product .Boldine displays anti-cancer cytoprotective anti-oxidant and anti-inflammatory activities.

Cell Viability Assay Cell Line:T24 and RT4 Concentration:10, 50, 100, 200, 300,400, 500 μM Incubation Time:24 h Result:Inhibited cell growth.Apoptosis Analysis Cell Line:T24Concentration:200, 400 μM Incubation Time:24 h Result:Caused a G2/M-phase arrest and a marked increase in cell deathWestern Blot Analysis Cell Line:T24 Concentration:200, 400 μM Incubation Time:1,, 3, 24 h Result:Decreased the level of p-ERK after 24 hours with 200 μM and after 3 and 24 hours with 400 μM.The anti-p-cdc2 antibody did not demonstrate any difference in the phosphorylation status of cdc2.Decreased the phosphorylation of GSK-3β after 24 hours at a concentration of 400 μM.

Animal Model:DSS-induced mice model Dosage:50 mg/kg Administration:p.o.Result: Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO) .Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA) .Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.

110-Dimethoxy-29-dihydroxyaporphine | ex Peumus boldus

Others

Other Targets

OPG |RANKL| RANK

——

——

476-70-0

327.37

C19H21NO4

>98% (HPLC)

DMSO:65 mg/mL (198.55 mM)

[H][C@@]12Cc3cc(O)c(OC)cc3-c3c(OC)c(O)cc(CCN1C)c23

110-DIMETHOXY-29-DIHYDROXYAPORPHINE

(-20℃)

With Ice Pack

≥ 2 years