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Bisdemethoxycurcumin

CAS No. 24939-16-0

Bisdemethoxycurcumin( Curcumin III, Bisdemethoxycurcumin )

Catalog No. M18307 CAS No. 24939-16-0

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bisdemethoxycurcumin
  • Note
    Research use only, not for human use.
  • Brief Description
    Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin.
  • Description
    Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Curcumin III, Bisdemethoxycurcumin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    p300|Wnt/β-catenin
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    24939-16-0
  • Formula Weight
    308.33
  • Molecular Formula
    C19H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 66.67 mg/mL (216.23 mM)
  • SMILES
    Oc2ccc(/C=C/C(=O)CC(=O)/C=C/c1ccc(O)cc1)cc2
  • Chemical Name
    (1E,6E)-1,7-Bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fiala, M., Liu, P.T., Espinosa-Jeffrey, A., et al. Proceedings of the National Academy of Sciences of the United States of America 104(31), 12849-12854 (2007).
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