Bindarit

CAS No. 130641-38-2

Bindarit( AF 2838 )

Catalog No. M11224 CAS No. 130641-38-2

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 68 In Stock
5MG 113 In Stock
10MG 177 In Stock
25MG 300 In Stock
50MG 447 In Stock
100MG 642 In Stock
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Biological Information

  • Product Name
    Bindarit
  • Note
    Research use only, not for human use.
  • Brief Description
    Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
  • Description
    Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.(In Vitro):Bindarit (10-300 μM; 48 hours) at 100 μM and 300 μM significantly inhibits platelet derived growth factor-BB (PDGF-BB)-induced rat VSMCs proliferation by 27% and 42%, respectively.(In Vivo):Bindarit (50 mg/kg; oral administration; every day; for 4 months, 6 months, 8 months; NZB/W F1 female mice) delays the onset of proteinuria and significantly protects from renal function impairment. Bindarit completely prevents monocyte chemoattractant protein (MCP-1) up-regulation.
  • In Vitro
    Cell Viability AssayCell Line:VSMC cells Concentration:10 μM, 30 μM, 100 μM, 300 μM Incubation Time:48 hours Result:Inhibited PDGF-BB-induced rat VSMCs proliferation.
  • In Vivo
    Animal Model:NZB/W F1 female mice ( two months of age)Dosage:50 mg/kg Administration:Oral administration; every day; for 4 months, 6 months, 8 months Result:Delayed the onset of proteinuria and significantly protected from renal function impairment.
  • Synonyms
    AF 2838
  • Pathway
    Autophagy
  • Target
    CCR
  • Recptor
    MCP-1/CCL2| MCP-2/CCL8| MCP-3/CCL7
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    130641-38-2
  • Formula Weight
    324.37
  • Molecular Formula
    C19H20N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:65 mg/mL (200.38 mM); Ethanol:65 mg/mL (200.38 mM); Water:<1 mg/mL (<1 mM)
  • SMILES
    CC(C)(OCC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3)C(O)=O
  • Chemical Name
    2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zoja C, et al. Kidney Int, 1998, 53(3), 726-734.
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