
Bindarit
CAS No. 130641-38-2
Bindarit( AF 2838 )
Catalog No. M11224 CAS No. 130641-38-2
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 68 | In Stock |
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5MG | 113 | In Stock |
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10MG | 177 | In Stock |
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25MG | 300 | In Stock |
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50MG | 447 | In Stock |
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100MG | 642 | In Stock |
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500MG | 1314 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameBindarit
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NoteResearch use only, not for human use.
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Brief DescriptionBindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
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DescriptionBindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.(In Vitro):Bindarit (10-300 μM; 48 hours) at 100 μM and 300 μM significantly inhibits platelet derived growth factor-BB (PDGF-BB)-induced rat VSMCs proliferation by 27% and 42%, respectively.(In Vivo):Bindarit (50 mg/kg; oral administration; every day; for 4 months, 6 months, 8 months; NZB/W F1 female mice) delays the onset of proteinuria and significantly protects from renal function impairment. Bindarit completely prevents monocyte chemoattractant protein (MCP-1) up-regulation.
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In VitroCell Viability AssayCell Line:VSMC cells Concentration:10 μM, 30 μM, 100 μM, 300 μM Incubation Time:48 hours Result:Inhibited PDGF-BB-induced rat VSMCs proliferation.
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In VivoAnimal Model:NZB/W F1 female mice ( two months of age)Dosage:50 mg/kg Administration:Oral administration; every day; for 4 months, 6 months, 8 months Result:Delayed the onset of proteinuria and significantly protected from renal function impairment.
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SynonymsAF 2838
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PathwayAutophagy
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TargetCCR
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RecptorMCP-1/CCL2| MCP-2/CCL8| MCP-3/CCL7
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number130641-38-2
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Formula Weight324.37
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Molecular FormulaC19H20N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:65 mg/mL (200.38 mM); Ethanol:65 mg/mL (200.38 mM); Water:<1 mg/mL (<1 mM)
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SMILESCC(C)(OCC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3)C(O)=O
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Chemical Name2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zoja C, et al. Kidney Int, 1998, 53(3), 726-734.
molnova catalog



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Bindarit
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.