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Bexagliflozin
CAS No. 1118567-05-7
Bexagliflozin( THR-1442 | EGT-1442 )
Catalog No. M10426 CAS No. 1118567-05-7
A potent and selective SGLT2 inhibitor with IC50 of 2 nM; shows little activity for SGLT1 (IC50=5.6 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 83 | In Stock |
|
| 5MG | 124 | In Stock |
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| 10MG | 186 | In Stock |
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| 25MG | 372 | In Stock |
|
| 50MG | 552 | In Stock |
|
| 100MG | 786 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBexagliflozin
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective SGLT2 inhibitor with IC50 of 2 nM; shows little activity for SGLT1 (IC50=5.6 uM).
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DescriptionA potent and selective SGLT2 inhibitor with IC50 of 2 nM; shows little activity for SGLT1 (IC50=5.6 uM); produces a saturable urinary glucose excretion in normal rats and dogs with ED50 of 0.38 and 0.09mg/kg, respectively; reduced HbA(1c) and blood glucose concentration without affecting body mass or insulin level in db/db mice.Diabetes Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsTHR-1442 | EGT-1442
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PathwayGPCR/G Protein
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TargetSGLT
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RecptorSGLT
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number1118567-05-7
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Formula Weight464.9359
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Molecular FormulaC24H29ClO7
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC[C@@H](O1)[C@@H](O)[C@H](O)[C@@H](O)C1C2=CC(CC(C=C3)=CC=C3OCCOC4CC4)=C(Cl)C=C2
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Chemical NameD-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang L, et al. Xenobiotica. 2016 Aug;46(8):703-8.
2. Zhang W, et al. Pharmacol Res. 2011 Apr;63(4):284-93.
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