Benzyl-PEG12-alcohol

CAS No. 2218463-17-1

Benzyl-PEG12-alcohol( —— )

Catalog No. M35140 CAS No. 2218463-17-1

Benzyl-PEG12-alcohol is a PEG-based linker for PROTACs, connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 76 Get Quote
5MG 55 Get Quote
10MG 81 Get Quote
25MG 118 Get Quote
50MG 164 Get Quote
100MG 232 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Benzyl-PEG12-alcohol
  • Note
    Research use only, not for human use.
  • Brief Description
    Benzyl-PEG12-alcohol is a PEG-based linker for PROTACs, connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.
  • Description
    Benzyl-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PROTACs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2218463-17-1
  • Formula Weight
    636.77
  • Molecular Formula
    C31H56O13
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC=1C=CC=CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
molnova catalog
related products
  • (2R,3S,11bS)-Dihydro...

    (2R,3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder.

  • 4-O-Methylhonokiol

    4-O-Methyl honokiol, a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist and inhibits NF-κB activity, used for cancer and inflammation research.

  • GSK-25

    GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).