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Balapiravir
CAS No. 690270-29-2
Balapiravir( R-1626 | R 1626 | Ro 4588161 | R1626 | Ro4588161 | Ro-4588161 )
Catalog No. M15642 CAS No. 690270-29-2
The prodrug of R1479, a potent, specific and oral HCV NS5B polymerase inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 295 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBalapiravir
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NoteResearch use only, not for human use.
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Brief DescriptionThe prodrug of R1479, a potent, specific and oral HCV NS5B polymerase inhibitor.
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DescriptionThe prodrug of R1479, a potent, specific and oral HCV NS5B polymerase inhibitor; demonstrates strong capacity to inhibit HCV replication in vitro and in vivo, without the rapid development of viral resistance.HCV Infection Phase 2 Discontinued.
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In Vitro——
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In VivoAfter oral dosing of the CD-1 mice with 28.1 mg/kg of balapiravir (Ro 4588161; R1626), R1479 reaches a Cmax and a minimum concentration in plasma (Cmin) of 24.38 μM and 6.34 μM, respectively, at 2 h and 24 h postdosing.
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SynonymsR-1626 | R 1626 | Ro 4588161 | R1626 | Ro4588161 | Ro-4588161
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCV
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number690270-29-2
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Formula Weight494.4983
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Molecular FormulaC21H30N6O8
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 100 mg/mL
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SMILESCC(C(O[C@H]([C@@H]([C@]1(COC(C(C)C)=O)N=[N+]=[N-])OC(C(C)C)=O)[C@@H](O1)N(C=CC(N)=N2)C2=O)=O)C
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Chemical NameCytidine, 4'-C-azido-, 2',3',5'-tris(2-methylpropanoate)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Roberts SK, et al. Hepatology. 2008 Aug;48(2):398-406.
2. McCown MF, et al. Antimicrob Agents Chemother. 2008 May;52(5):1604-12.
3. Chen YL, et al. J Virol. 2014 Feb;88(3):1740-7.
4. Toniutto P, et al. IDrugs. 2008 Oct;11(10):738-49.
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