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Home - Products - Microbiology/Virology - HCV - GS-9451

GS-9451

CAS No. 1310824-24-8

GS-9451( GS9451 | Vedroprevir )

Catalog No. M11250 CAS No. 1310824-24-8

GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GS-9451
  • Note
    Research use only, not for human use.
  • Brief Description
    GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.
  • Description
    GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays; exhibits low toxicity and high selectivity over mammalian proteases.HCV Infection Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GS9451 | Vedroprevir
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCV
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    1310824-24-8
  • Formula Weight
    910.525
  • Molecular Formula
    C45H60ClN7O9S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCC1CC1(C(=O)O)NC(=O)C2CC(CN2C(=O)C(C(C)(C)C)NC(=O)OC3CC4CC4C3)OC5=CC(=NC6=C5C=CC(=C6Cl)OCCN7CCOCC7)C8=CSC(=N8)NC(C)C
  • Chemical Name
    (1R,2R)-1-((2S)-1-((S)-2-(((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropane-1-carboxylic

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sheng XC, et al. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2629-34. 2. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5289-95. 3. Yang H, et al. Antimicrob Agents Chemother. 2014;58(2):647-53.
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