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BX795
CAS No. 702675-74-9
BX795( BX 795 | BX-795 )
Catalog No. M15696 CAS No. 702675-74-9
BX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM; also inhibits TBK1 and IKKε with IC50 of 6 nM and 41 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 49 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 198 | In Stock |
|
| 50MG | 324 | In Stock |
|
| 100MG | 486 | In Stock |
|
| 200MG | 701 | In Stock |
|
| 500MG | 1062 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBX795
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NoteResearch use only, not for human use.
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Brief DescriptionBX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM; also inhibits TBK1 and IKKε with IC50 of 6 nM and 41 nM.
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DescriptionBX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM; also inhibits TBK1 and IKKε with IC50 of 6 nM and 41 nM; shows no activity for PKA, PKC, c-Kit, GSK3β, IKKα, IKKβ, etc.; blocks the autophosphorylation of overexpressed TBK1 and IKKepsilon at Ser-172; has no effect on the canonical NFkappaB signaling pathway.
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In Vitro——
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In Vivo——
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SynonymsBX 795 | BX-795
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PathwayPI3K/Akt/mTOR signaling
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TargetPDK
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RecptorCDK2/CyclinE|Chk1|c-Kit|PDK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number702675-74-9
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Formula Weight591.4677
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Molecular FormulaC23H26IN7O2S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(I)C(NCCCNC(C4=CC=CS4)=O)=N3)=C2
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Chemical Name1-Pyrrolidinecarboxamide, N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Clark K, et al. J Biol Chem. 2009 May 22;284(21):14136-46.
2. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.
3. Frémond ML, et al. Arthritis Rheumatol. 2017 Apr 20. doi: 10.1002/art.40122.
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