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KPLH1130

CAS No. 906669-07-6

KPLH1130( —— )

Catalog No. M24944 CAS No. 906669-07-6

KPLH1130 improves glucose tolerance in HFD-fed mice.?KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KPLH1130
  • Note
    Research use only, not for human use.
  • Brief Description
    KPLH1130 improves glucose tolerance in HFD-fed mice.?KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.
  • Description
    KPLH1130 improves glucose tolerance in HFD-fed mice.?KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PDK
  • Recptor
    PDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    906669-07-6
  • Formula Weight
    283.28
  • Molecular Formula
    C15H13N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:130 mg/mL (458.91 mM; Need ultrasonic)
  • SMILES
    O=C1NN=C(C2=CC=C(O)C=C2O)N1C3=CC=C(C)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944.
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