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BVDV-IN-1

CAS No. 345651-04-9

BVDV-IN-1( —— )

Catalog No. M24294 CAS No. 345651-04-9

BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.?It directly binds to a hydrophobic pocket of the BVDV RdRp.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BVDV-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.?It directly binds to a hydrophobic pocket of the BVDV RdRp.
  • Description
    BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM.?It directly binds to a hydrophobic pocket of the BVDV RdRp. It has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).
  • In Vitro
    BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp).BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    345651-04-9
  • Formula Weight
    334.42
  • Molecular Formula
    C20H22N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 250 mg/mL (747.59 mM; Need ultrasonic)
  • SMILES
    OCCN1CCN(C2=C3C=CC=CC3=NC(C4=CC=CC=C4)=N2)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gabriela A Fernández, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235.
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