BSJ-4-116 ( —— )

Catalog No. M24142 CAS No. 2519823-34-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

BSJ-4-116
Note

Research use only, not for human use.
Brief Description

BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM.?It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
Description

BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM.?It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK12;Cereblon
Research Area

——
Indication

——

CAS Number

2519823-34-6
Formula Weight

837.4
Molecular Formula

C40H49ClN8O8S
Purity

>98% (HPLC)
Solubility

DMSO:250 mg/mL (298.55 mM; Need ultrasonic)
SMILES

O=C(NCCCCCCCN1C[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CCC1)COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O
Chemical Name

——

1.Jiang B, et al. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021;17(6):675-683.

Calculator

molnova catalog