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BSJ-4-116
CAS No. 2519823-34-6
BSJ-4-116 ( —— )
Catalog No. M24142 CAS No. 2519823-34-6
BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM.?It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 120 | In Stock |
|
| 10MG | 203 | In Stock |
|
| 25MG | 441 | In Stock |
|
| 50MG | 651 | In Stock |
|
| 100MG | 888 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBSJ-4-116
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NoteResearch use only, not for human use.
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Brief DescriptionBSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM.?It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
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DescriptionBSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM.?It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK12;Cereblon
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Research Area——
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Indication——
Chemical Information
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CAS Number2519823-34-6
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Formula Weight837.4
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Molecular FormulaC40H49ClN8O8S
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (298.55 mM; Need ultrasonic)
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SMILESO=C(NCCCCCCCN1C[C@H](NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(C(C)C)=O)=N2)CCC1)COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jiang B, et al. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021;17(6):675-683.
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