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BRD3308
CAS No. 1550053-02-5
BRD3308 ( BRD 3308 )
Catalog No. M12199 CAS No. 1550053-02-5
BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | Get Quote |
|
| 5MG | 78 | Get Quote |
|
| 10MG | 115 | Get Quote |
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| 25MG | 210 | Get Quote |
|
| 50MG | 317 | Get Quote |
|
| 100MG | 475 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBRD3308
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NoteResearch use only, not for human use.
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Brief DescriptionBRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM.
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DescriptionBRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms; attenuates PE-mediated phosphorylation of ERK, but not JNK; also activates HIV-1 transcription in the 2D10 cell line, induces outgrowth of HIV-1 from resting CD4+ T cells isolated from antiretroviral-treated, aviremic HIV+ patients ex vivo and disrupts HIV-1 latency; suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release.
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SynonymsBRD 3308
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1550053-02-5
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Formula Weight287.29
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Molecular FormulaC15H14FN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(F)C=C1N)C2=CC=C(NC(C)=O)C=C2
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Chemical Name4-Acetylamino-N-(2-amino-4-fluorophenyl)-benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ferguson BS, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11.
2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684.
3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74.
2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684.
3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74.
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