BRD3308
CAS No. 1550053-02-5
BRD3308 ( BRD 3308 )
Catalog No. M12199 CAS No. 1550053-02-5
BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 49 | Get Quote |
|
5MG | 78 | Get Quote |
|
10MG | 115 | Get Quote |
|
25MG | 210 | Get Quote |
|
50MG | 317 | Get Quote |
|
100MG | 475 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBRD3308
-
NoteResearch use only, not for human use.
-
Brief DescriptionBRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM.
-
DescriptionBRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms; attenuates PE-mediated phosphorylation of ERK, but not JNK; also activates HIV-1 transcription in the 2D10 cell line, induces outgrowth of HIV-1 from resting CD4+ T cells isolated from antiretroviral-treated, aviremic HIV+ patients ex vivo and disrupts HIV-1 latency; suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release.
-
SynonymsBRD 3308
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHDAC
-
Research AreaMetabolic Disease
-
Indication——
Chemical Information
-
CAS Number1550053-02-5
-
Formula Weight287.29
-
Molecular FormulaC15H14FN3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(NC1=CC=C(F)C=C1N)C2=CC=C(NC(C)=O)C=C2
-
Chemical Name4-Acetylamino-N-(2-amino-4-fluorophenyl)-benzamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ferguson BS, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11.
2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684.
3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74.
2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684.
3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74.
molnova catalog
related products
-
HDAC6-AR-IN-10
HDAC6-AR-IN-10 is a potent dual HDAC6/AR inhibitor with IC50 of 35.6 nM/<30 nM.
-
Apicidin
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro.
-
Tubacin
Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM.