BRD-7880( BRD 7880 | BRD7880 )

Catalog No. M11969 CAS No. 1456542-69-0

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Product Name

BRD-7880
Note

Research use only, not for human use.
Brief Description

A potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively.
Description

A potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM); is far more selective than tozasertib (VX-680), substantially inhibiting (to < 25% control activity) only AURKB and AURKC in a panel of 308 kinases.
In Vitro

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In Vivo

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Synonyms

BRD 7880 | BRD7880
Pathway

Cell Cycle/DNA Damage
Target

Aurora Kinase
Recptor

Aurora Kinase
Research Area

——
Indication

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CAS Number

1456542-69-0
Formula Weight

590.677
Molecular Formula

C32H38N4O7
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CC=C(OC)C=C1)NC2=CC=C(O[C@@H](CN(CC3=CC=C(OCO4)C4=C3)C)[C@@H](C)CN([C@@H](C)CO)C5=O)C5=C2
Chemical Name

1-((2R,3S)-2-(((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)methyl)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-8-yl)-3-(4-methoxyphenyl)urea

1. Yu C, et al. Nat Biotechnol. 2016 Apr;34(4):419-23.

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