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BOS-318
CAS No. 2387633-15-8
BOS-318 ( —— )
Catalog No. M28989 CAS No. 2387633-15-8
BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | Get Quote |
|
| 10MG | 143 | Get Quote |
|
| 25MG | 290 | Get Quote |
|
| 50MG | 462 | Get Quote |
|
| 100MG | 672 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBOS-318
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NoteResearch use only, not for human use.
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Brief DescriptionBOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.
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DescriptionBOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.(In Vitro):BOS-318 (0.001-1 μM) provides cytoprotection against toxicity in CuFi-1 cells induced by P aeruginosa exotoxin A (PEA). BOS-318 (U2OS cells) to be approximately 13 times more potent against furin than PCSK5 (IC50 = 25.3 nM), 24 times more potent that PCSK7 (IC50 = 45.8 nM), and 110 times more potent than PCSK6 (IC50 = 209.4 nM). BOS-318 (0.3 μM, 2h or 48 h)reduces ENaC-mediated Na+ absorption in CF HBECs and protects aganist NE- and CF sputum-sol-mediated activation of ENaC.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2387633-15-8
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Formula Weight423.4
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Molecular FormulaC17H31NO7P2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCCCCCCCOc1ccc[n+](CC(P([O-])(O)=O)P(O)(O)=O)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.
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