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BMT-090605

CAS No. 1551403-51-0

BMT-090605( BMT 090605 | BMT090605 )

Catalog No. M12203 CAS No. 1551403-51-0

BMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BMT-090605
  • Note
    Research use only, not for human use.
  • Brief Description
    BMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM.
  • Description
    BMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM; weakly inhibits BIKE and GAK with IC50 of 45 and 60 nM, respectively.
  • In Vitro
    BMT-090605 shows AAK1inhibitory activity with an IC50 of 0.63 nM.BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively.
  • In Vivo
    BMT-090605 (intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord. Animal Model:Male Sprague-Dawley rats (chronic constriction injury (CCI) model)Dosage:0.3-3 μg/rat Administration:Intrathecal Result:Caused a dose-dependent reduction in thermal hyperalgesia.
  • Synonyms
    BMT 090605 | BMT090605
  • Pathway
    Others
  • Target
    AAK1
  • Recptor
    AAK1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1551403-51-0
  • Formula Weight
    364.449
  • Molecular Formula
    C21H24N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O
  • Chemical Name
    (S)-8-((2-amino-4-methylpentyl)oxy)-4,6-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-9-carbonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kostich W, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.
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