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BMT-090605
CAS No. 1551403-51-0
BMT-090605( BMT 090605 | BMT090605 )
Catalog No. M12203 CAS No. 1551403-51-0
BMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1233 | Get Quote |
|
| 50MG | 2502 | Get Quote |
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| 100MG | 3330 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBMT-090605
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NoteResearch use only, not for human use.
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Brief DescriptionBMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM.
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DescriptionBMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM; weakly inhibits BIKE and GAK with IC50 of 45 and 60 nM, respectively.
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In VitroBMT-090605 shows AAK1inhibitory activity with an IC50 of 0.63 nM.BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively.
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In VivoBMT-090605 (intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord. Animal Model:Male Sprague-Dawley rats (chronic constriction injury (CCI) model)Dosage:0.3-3 μg/rat Administration:Intrathecal Result:Caused a dose-dependent reduction in thermal hyperalgesia.
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SynonymsBMT 090605 | BMT090605
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PathwayOthers
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TargetAAK1
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RecptorAAK1
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Research Area——
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Indication——
Chemical Information
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CAS Number1551403-51-0
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Formula Weight364.449
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Molecular FormulaC21H24N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O
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Chemical Name(S)-8-((2-amino-4-methylpentyl)oxy)-4,6-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-9-carbonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kostich W, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.
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