BMS-986235
CAS No. 2253947-47-4
BMS-986235 ( LAR-1219 )
Catalog No. M28238 CAS No. 2253947-47-4
BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 335 | Get Quote |
|
10MG | 500 | Get Quote |
|
25MG | 806 | Get Quote |
|
50MG | 1098 | Get Quote |
|
100MG | 1485 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBMS-986235
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively.
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DescriptionBMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.(In Vitro):BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation.(In Vivo):In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L?h, and 24%, respectively.
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SynonymsLAR-1219
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PathwayOthers
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TargetOther Targets
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RecptorLDL;TNF-α;Antioxidant
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Research Area——
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Indication——
Chemical Information
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CAS Number2253947-47-4
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Formula Weight361.3
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Molecular FormulaC18H17F2N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC=1C=CC=CC1)NC2C(=O)NCC2C=3C(F)=CC(OC)=CC3F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sharma S, et al. Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether. Eur J Med Chem. 2010;45(11):5150-5156.
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