BMS-986235

CAS No. 2253947-47-4

BMS-986235 ( LAR-1219 )

Catalog No. M28238 CAS No. 2253947-47-4

BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 335 Get Quote
10MG 500 Get Quote
25MG 806 Get Quote
50MG 1098 Get Quote
100MG 1485 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    BMS-986235
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively.
  • Description
    BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.(In Vitro):BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation.(In Vivo):In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L?h, and 24%, respectively.
  • Synonyms
    LAR-1219
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    LDL;TNF-α;Antioxidant
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2253947-47-4
  • Formula Weight
    361.3
  • Molecular Formula
    C18H17F2N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC=1C=CC=CC1)NC2C(=O)NCC2C=3C(F)=CC(OC)=CC3F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sharma S, et al. Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether. Eur J Med Chem. 2010;45(11):5150-5156.
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