BMS-962212( BMS962212 )

Catalog No. M11818 CAS No. 1430114-34-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-962212
Note

Research use only, not for human use.
Brief Description

BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM.
Description

BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM; displays an excellent protease selectivity profile, including thrombin, Factor Xa/VIIa/IXa/XIIa, plasma or tissue kallikrein; shows excellent preclinical efficacy in thrombosis models and aqueous solubility suitable for intravenous administration.Thrombosis Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

BMS962212
Pathway

Metabolic Enzyme/Protease
Target

Factor Xa
Recptor

Factor Xa
Research Area

Cardiovascular Disease
Indication

Thrombosis

CAS Number

1430114-34-3
Formula Weight

659.075
Molecular Formula

C32H28ClFN8O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (379.32 mM)
SMILES

CN1CCN(C(=O)C1)C2=CC=CC3=C2CCN(C3C(=O)NC4=CC=C(C=C4)C(=O)O)C(=O)C=CC5=C(C=CC(=C5F)Cl)N6C=NN=N6
Chemical Name

(S,E)-4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

1. Pinto DJP, et al. J Med Chem. 2017 Dec 14;60(23):9703-9723. 2. Perera V, et al. Br J Clin Pharmacol. 2018 Jan 18. doi: 10.1111/bcp.13520.

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