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BMS-955176

CAS No. 1392312-45-6

BMS-955176 ( GSK-3532795;BMS955176 )

Catalog No. M11631 CAS No. 1392312-45-6

BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BMS-955176
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.
  • Description
    BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses; exhibits median EC50 of 21 nM toward a library of subtype B clinical isolates assayed in PBMCs; inhibits HIV-1 protease cleavage at the CA/SP1 junction within Gag in VLPs and in HIV-1-infected cells, and binds reversibly and with high affinity to assembled Gag in purified HIV-1 VLPs; has a greatly improved preclinical profile compared to that of Bevirimat.HIV Infection Phase 2 Clinical
  • Synonyms
    GSK-3532795;BMS955176
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    1392312-45-6
  • Formula Weight
    691.03
  • Molecular Formula
    C42H62N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(=C)C1CCC2(C1C3CCC4C(C3(CC2)C)(CCC5C4(CC=C(C5(C)C)C6=CC=C(C=C6)C(=O)O)C)C)NCCN7CCS(=O)(=O)CC7
  • Chemical Name
    Benzoic acid, 4-[17-[[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]amino]-28-norlupa-2,20(29)-dien-3-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nowicka-Sans B, et al. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3956-69.
2. Regueiro-Ren A, et al. ACS Med Chem Lett. 2016 Apr 22;7(6):568-72.
3. Lin Z, et al. PLoS Pathog. 2016 Nov 28;12(11):e1005990.
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