BMS-955176
CAS No. 1392312-45-6
BMS-955176 ( GSK-3532795;BMS955176 )
Catalog No. M11631 CAS No. 1392312-45-6
BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 860 | Get Quote |
|
50MG | 2322 | Get Quote |
|
100MG | 3060 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBMS-955176
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.
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DescriptionBMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses; exhibits median EC50 of 21 nM toward a library of subtype B clinical isolates assayed in PBMCs; inhibits HIV-1 protease cleavage at the CA/SP1 junction within Gag in VLPs and in HIV-1-infected cells, and binds reversibly and with high affinity to assembled Gag in purified HIV-1 VLPs; has a greatly improved preclinical profile compared to that of Bevirimat.HIV Infection Phase 2 Clinical
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SynonymsGSK-3532795;BMS955176
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number1392312-45-6
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Formula Weight691.03
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Molecular FormulaC42H62N2O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(=C)C1CCC2(C1C3CCC4C(C3(CC2)C)(CCC5C4(CC=C(C5(C)C)C6=CC=C(C=C6)C(=O)O)C)C)NCCN7CCS(=O)(=O)CC7
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Chemical NameBenzoic acid, 4-[17-[[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]amino]-28-norlupa-2,20(29)-dien-3-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nowicka-Sans B, et al. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3956-69.
2. Regueiro-Ren A, et al. ACS Med Chem Lett. 2016 Apr 22;7(6):568-72.
3. Lin Z, et al. PLoS Pathog. 2016 Nov 28;12(11):e1005990.
2. Regueiro-Ren A, et al. ACS Med Chem Lett. 2016 Apr 22;7(6):568-72.
3. Lin Z, et al. PLoS Pathog. 2016 Nov 28;12(11):e1005990.
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