BMS-818251( BMS818251 | BMS 818251 )

Catalog No. M17093 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BMS-818251
Note

Research use only, not for human use.
Brief Description

BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3.
Description

BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3; displays >10-fold more potent than temsavir on a cross-clade panel of 208-HIV-1 strains, interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency.
In Vitro

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In Vivo

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Synonyms

BMS818251 | BMS 818251
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

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Indication

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CAS Number

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Formula Weight

570.624
Molecular Formula

C29H26N6O5S
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(C1=NC(C2=NC=C(OC)C3=C2NC=C3C(C(N4CC/C(CC4)=C(C#N)\C5=CC=CC=C5)=O)=O)=CS1)NCCO
Chemical Name

4-(3-(2-(4-(cyano(phenyl)methylene)piperidin-1-yl)-2-oxoacetyl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)-N-(2-hydroxyethyl)thiazole-2-carboxamide

1. Lai YT, et al. Nat Commun. 2019 Jan 3;10(1):47. doi: 10.1038/s41467-018-07851-1.

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