BMS-818251

CAS No.

BMS-818251 ( BMS818251;BMS 818251 )

Catalog No. M17093 CAS No.

BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BMS-818251
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3.
  • Description
    BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3; displays >10-fold more potent than temsavir on a cross-clade panel of 208-HIV-1 strains, interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency.
  • Synonyms
    BMS818251;BMS 818251
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    570.62
  • Molecular Formula
    C29H26N6O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=NC(C2=NC=C(OC)C3=C2NC=C3C(C(N4CC/C(CC4)=C(C#N)\C5=CC=CC=C5)=O)=O)=CS1)NCCO
  • Chemical Name
    4-(3-(2-(4-(cyano(phenyl)methylene)piperidin-1-yl)-2-oxoacetyl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)-N-(2-hydroxyethyl)thiazole-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lai YT, et al. Nat Commun. 2019 Jan 3;10(1):47. doi: 10.1038/s41467-018-07851-1.
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