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BMS-813160
CAS No. 1286279-29-5
BMS-813160( —— )
Catalog No. M17924 CAS No. 1286279-29-5
BMS-813160 is the first dual?CCR2/CCR5?antagonist to enter Clinical development for cardiovascular.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 125 | In Stock |
|
| 10MG | 177 | In Stock |
|
| 25MG | 323 | In Stock |
|
| 50MG | 537 | In Stock |
|
| 100MG | 767 | In Stock |
|
| 500MG | 1557 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-813160
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-813160 is the first dual?CCR2/CCR5?antagonist to enter Clinical development for cardiovascular.
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DescriptionBMS-813160 is the first dual?CCR2/CCR5?antagonist to enter Clinical development for cardiovascular.(In Vitro):BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively.BMS-813160 shows activities to CCR2 CTX, CCR2 CD11b, CCR5 CTX and CCR5 CD11b with IC50s of 0.8, 4.8, 1.1 and 5.7 nM, respectively.(In Vivo):BMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability.
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In VitroBMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively.BMS-813160 shows activities to CCR2 CTX, CCR2 CD11b, CCR5 CTX and CCR5 CD11b with IC50s of 0.8, 4.8, 1.1 and 5.7 nM, respectively.
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In VivoBMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability. Animal Model:Human-CCR2 knock-in C57BL/6 male mice with thioglycollate injectionDosage:10, 50 and 160 mg/kg Administration:Oral gavage; 10-160 mg/kg twice a day; for two days Result:Dose-dependently reduced inflammatory monocyte and macrophage infiltration in the peritoneum.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorCCR2|CCR5
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Research Area——
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Indication——
Chemical Information
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CAS Number1286279-29-5
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Formula Weight484.64
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Molecular FormulaC25H40N8O2
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Purity>98% (HPLC)
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SolubilityDMSO : 25 mg/mL 51.58 mM;
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SMILESCC(C)(C)N[C@@H]1CC[C@@H]([C@H](NC(C)=O)C1)N4CC[C@H](Nc2ncnc3cc(nn23)C(C)(C)C)C4=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Norman P. et al. A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of WO2011046916. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24.
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