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BMS-309403
CAS No. 300657-03-8
BMS-309403( BMS309403 )
Catalog No. M13930 CAS No. 300657-03-8
A potent, selective, cell-permeable and orally active inhibitor of FABP4 (Fatty acid binding protein 4) with Ki of < 2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 27 | In Stock |
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| 5MG | 43 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 149 | In Stock |
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| 50MG | 194 | In Stock |
|
| 100MG | 252 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-309403
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, cell-permeable and orally active inhibitor of FABP4 (Fatty acid binding protein 4) with Ki of < 2 nM.
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DescriptionA potent, selective, cell-permeable and orally active inhibitor of FABP4 (Fatty acid binding protein 4) with Ki of < 2 nM; improves endothelial function, phosphorylated and total eNOS and reduces plasma triglyceride levels but does not affect endothelium-independent relaxations in mice; exhibits an effective therapeutic activity against severe atherosclerosis and type 2 diabetes in mouse models.
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In Vitro——
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In VivoAnimal Model:C57BL/6J mice (ApoE?/? mice)Dosage:15 mg/kg Administration:Chronic treatment ; daily for 6 weeks Result: Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE?/? mice.
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SynonymsBMS309403
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PathwayMembrane Transporter/Ion Channel
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TargetFABP
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RecptorFABP4|FABP3|FABP5
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Research Area——
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Indication——
Chemical Information
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CAS Number300657-03-8
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Formula Weight474.55
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Molecular FormulaC31H26N2O3
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Purity>98% (HPLC)
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Solubility100 mM in DMSO
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SMILESCCc1c(c(nn1c2ccccc2c3cccc(c3)OCC(=O)O)c4ccccc4)c5ccccc5
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Chemical Name2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Furuhashi M, et al. Nature. 2007 Jun 21;447(7147):959-65.
2. Lee MY, et al. Br J Pharmacol. 2011 Apr;162(7):1564-76.
3. Sulsky R, et al. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5.
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