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BMS-3

CAS No. 1338247-30-5

BMS-3 ( BMS-3; BMS 3; BMS3 )

Catalog No. M17955 CAS No. 1338247-30-5

BMS-3 is a potentLIMKinhibitor withIC50s of 5 nM and 6 nM forLIMK1andLIMK2, respectively.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 219 In Stock
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Biological Information

  • Product Name
    BMS-3
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-3 is a potentLIMKinhibitor withIC50s of 5 nM and 6 nM forLIMK1andLIMK2, respectively.
  • Description
    BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 μM BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
  • Synonyms
    BMS-3; BMS 3; BMS3
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    LIMK1;LIMK2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1338247-30-5
  • Formula Weight
    429.27
  • Molecular Formula
    C17H12Cl2F2N4OS
  • Purity
    98%
  • Solubility
    DMSO : ≥ 30 mg/mL6; 9.89 mM
  • SMILES
    O=C(Nc1ncc(s1)c2cc(nn2c3c(Cl)cccc3Cl)C(F)F)C4CC4
  • Chemical Name
    N-[5-[2-(2,6-Dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8.
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