BMS-3 ( BMS-3; BMS 3; BMS3 )

Catalog No. M17955 CAS No. 1338247-30-5

BMS-3 is a potentLIMKinhibitor withIC50s of 5 nM and 6 nM forLIMK1andLIMK2, respectively.

Purity : 98%

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

BMS-3
Note

Research use only, not for human use.
Brief Description

BMS-3 is a potentLIMKinhibitor withIC50s of 5 nM and 6 nM forLIMK1andLIMK2, respectively.
Description

BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 μM BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
Synonyms

BMS-3; BMS 3; BMS3
Pathway

Others
Target

Other Targets
Recptor

LIMK1;LIMK2
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1338247-30-5
Formula Weight

429.27
Molecular Formula

C17H12Cl2F2N4OS
Purity

98%
Solubility

DMSO : ≥ 30 mg/mL6; 9.89 mM
SMILES

O=C(Nc1ncc(s1)c2cc(nn2c3c(Cl)cccc3Cl)C(F)F)C4CC4
Chemical Name

N-[5-[2-(2,6-Dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8.

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