BML-190( BML-190 | BML 190 | BML190 | Indomethacin Morpholinylamide. )

Catalog No. M18363 CAS No. 2854-32-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BML-190
Note

Research use only, not for human use.
Brief Description

BML-190 is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.
Description

BML-190, also known as IMMA and LM-4131 or Indomethacin Morpholinylamide, is selective CB2 receptor agonist. The binding constant for the CB2 receptor is 435 nM compared to >20,000 nM for the cannabinoid receptor, CB1. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB(2) receptor and 16z44. BML-190 acts as inverse agonist at the human CB(2) receptor acting via G alpha(i/o) and G alpha(q) family-coupled pathways.
In Vitro

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In Vivo

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Synonyms

BML-190 | BML 190 | BML190 | Indomethacin Morpholinylamide.
Pathway

Apoptosis
Target

NF-κB
Recptor

CB2
Research Area

Cancer
Indication

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CAS Number

2854-32-2
Formula Weight

426.89
Molecular Formula

C23H23ClN2O4
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 117.13 mM;
SMILES

Cc1c(c2c(n1C(=O)c1ccc(cc1)Cl)ccc(c2)OC)CC(=O)N1CCOCC1
Chemical Name

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-ethanone

1. New DC, et al. FEBS Lett. 2003, 536(1-3), 157-160.

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