BMH-21

Research use only, not for human use.

BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM.

BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription; inhibits the expression of 47S rRNA transcript with IC50 of 60 nM, blocks transcription of the rRNA precursor without affecting rRNA maturation, and causes segregation of nucleolar proteins; causes proteasome-mediated degradation of RPA194 (Pol I catalytic subunit); activates p53 and inhibits TP53 null and mutant cell lines with GI50 of 110 and 205 nM, respectively.

BMH21

Cell Cycle/DNA Damage

DNA/RNA Synthesis

RNApolymeraseI

Cancer

——

896705-16-1

360.41

C21H20N4O2

>98% (HPLC)

10 mM in DMSO

O=C(C1=CC=CN2C1=NC3C=C(C=CC=C4)C4=CC3C2=O)NCCN(C)C

12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-

(-20℃)

With Ice Pack

≥ 2 years