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BL-1020
CAS No. 503537-33-5
BL-1020( BL1020 | BL 1020 )
Catalog No. M14710 CAS No. 503537-33-5
BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBL-1020
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NoteResearch use only, not for human use.
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Brief DescriptionBL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist.
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DescriptionBL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist; reduces dopamine activity and enhances GABAA activity, shows pro-cognitive effects and potential for the treatment of schizophrenia; displays strong dopamine and serotonin (5HT) receptor inhibition ((D2LK(iz)=0.066 nM, D(2S)Ki=0.062 nM, 5-HT2A Ki=0.21 nM).Schizophrenia Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsBL1020 | BL 1020
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number503537-33-5
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Formula Weight525.533
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Molecular FormulaC25H34Cl2N4O2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 4-aminobutanoate hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Geffen Y, et al. Eur Neuropsychopharmacol. 2009 Jan;19(1):1-13.
2. Nudelman A, et al. J Med Chem. 2008 May 8;51(9):2858-62.
3. Appel L, et al. Eur Neuropsychopharmacol. 2009 Dec;19(12):841-50.
4. Geffen Y, et al. J Clin Psychiatry. 2012 Sep;73(9):e1168-74.
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