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Home - Products - GPCR/G Protein - Dopamine Receptor - BL-1020

BL-1020

CAS No. 503537-33-5

BL-1020( BL1020 | BL 1020 )

Catalog No. M14710 CAS No. 503537-33-5

BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BL-1020
  • Note
    Research use only, not for human use.
  • Brief Description
    BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist.
  • Description
    BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist; reduces dopamine activity and enhances GABAA activity, shows pro-cognitive effects and potential for the treatment of schizophrenia; displays strong dopamine and serotonin (5HT) receptor inhibition ((D2LK(iz)=0.066 nM, D(2S)Ki=0.062 nM, 5-HT2A Ki=0.21 nM).Schizophrenia Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BL1020 | BL 1020
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    503537-33-5
  • Formula Weight
    525.533
  • Molecular Formula
    C25H34Cl2N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 4-aminobutanoate hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Geffen Y, et al. Eur Neuropsychopharmacol. 2009 Jan;19(1):1-13. 2. Nudelman A, et al. J Med Chem. 2008 May 8;51(9):2858-62. 3. Appel L, et al. Eur Neuropsychopharmacol. 2009 Dec;19(12):841-50. 4. Geffen Y, et al. J Clin Psychiatry. 2012 Sep;73(9):e1168-74.
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