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FAUC-365

CAS No. 474432-66-1

FAUC-365( FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide )

Catalog No. M27448 CAS No. 474432-66-1

FAUC-365 is a D3 dopamine receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FAUC-365
  • Note
    Research use only, not for human use.
  • Brief Description
    FAUC-365 is a D3 dopamine receptor agonist.
  • Description
    FAUC-365 is a D3 dopamine receptor agonist.(In Vitro):As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    LOXL2|LOXL3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    474432-66-1
  • Formula Weight
    462.43
  • Molecular Formula
    C23H25Cl2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (72.07 mM)
  • SMILES
    Clc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Findlay AD,et al. Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3. J Med Chem. 2019 Nov 14;62(21):9874-9889.
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