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Home - Products - Chromatin/Epigenetic - HMTase - BIX-01294

BIX-01294

CAS No. 935693-62-2

BIX-01294 ( BIX 01294;BIX01294 )

Catalog No. M16693 CAS No. 935693-62-2

A specific small molecule G9a histone methyltransferase inhibitor with IC50 of 1.7 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 42 Get Quote
5MG 69 Get Quote
10MG 107 Get Quote
25MG 196 Get Quote
50MG 332 Get Quote
100MG 491 Get Quote
200MG 700 Get Quote
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Biological Information

  • Product Name
    BIX-01294
  • Note
    Research use only, not for human use.
  • Brief Description
    A specific small molecule G9a histone methyltransferase inhibitor with IC50 of 1.7 uM.
  • Description
    A specific small molecule G9a histone methyltransferase inhibitor with IC50 of 1.7 uM; weakly inhibits the closely related GLP enzyme (IC50=38 uM), no inhibition of the other HMTases (>45 uM); reduces H3K9me2 of bulk histones in several cell lines, enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts combined with BayK8644; also can reactivate expression of HIV-1 from latently infected cells.
  • Synonyms
    BIX 01294;BIX01294
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    935693-62-2
  • Formula Weight
    490.64
  • Molecular Formula
    C28H38N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC
  • Chemical Name
    4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kubicek S, et al. Mol Cell. 2007 Feb 9;25(3):473-81.
2. Shi Y, et al. Cell Stem Cell. 2008 Nov 6;3(5):568-74.
3. Chang Y, et al. Nat Struct Mol Biol. 2009 Mar;16(3):312-7.
4. Imai K, et al. J Biol Chem. 2010 May 28;285(22):16538-45.
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