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Home - Products - PI3K/Akt/mTOR signaling - GSK-3 - BIO

BIO

CAS No. 667463-62-9

BIO( 6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052 )

Catalog No. M15548 CAS No. 667463-62-9

A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BIO
  • Note
    Research use only, not for human use.
  • Brief Description
    A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.
  • Description
    A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM; also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM); maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog; promotes proliferation in mammalian cardiomyocytes.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    CDK1/CyclinB|CDK2/CyclinA|CDK5/p35|GSK-3|Tyk2
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    667463-62-9
  • Formula Weight
    356.1735
  • Molecular Formula
    C16H10BrN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 23 mg/mL
  • SMILES
    O=C(/C1=C2NC3=C(C\2=N/O)C=CC=C3)NC4=C1C=CC(Br)=C4
  • Chemical Name
    2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Meijer L, et al. Chem Biol. 2003 Dec;10(12):1255-66. 2. Tseng AS, et al. Chem Biol. 2006 Sep;13(9):957-63. 3. Sato N, et al. Nat Med. 2004 Jan;10(1):55-63.
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