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CP21R7
CAS No. 125314-13-8
CP21R7( CP21 )
Catalog No. M11014 CAS No. 125314-13-8
A high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 70 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 141 | In Stock |
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| 25MG | 258 | In Stock |
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| 50MG | 438 | In Stock |
|
| 100MG | 642 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCP21R7
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NoteResearch use only, not for human use.
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Brief DescriptionA high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling.
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DescriptionA high-affinity, selective GSK3β inhibitor that activates canonical Wnt signaling; promotes rapid and efficient differentiation of human pluripotent stem cells (hPSCs) into vascular endothelial and smooth muscle cells.(In Vitro):CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.
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In VitroCP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.
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In Vivo——
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SynonymsCP21
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3β
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number125314-13-8
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Formula Weight317.3413
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Molecular FormulaC19H15N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO=C(C(C1=CC=CC(N)=C1)=C2C3=CN(C)C4=C3C=CC=C4)NC2=O
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Chemical Name1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patsch C, et al. Nat Cell Biol. 2015 Aug;17(8):994-1003.
2. Sahara M, et al. Cell Res. 2014 Jul;24(7):820-41.
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