BIBS-39

Research use only, not for human use.

BIBS-39 is a selective nonpeptide angiotensin II receptor antagonist with Ki of 29 nM and 480 nM for AT1 and AT2 respectively.

BIBS-39 is a selective nonpeptide angiotensin II receptor antagonist with Ki of 29 nM and 480 nM for AT1 and AT2 respectively; shows no high affinity for other receptors, shifts the AII concentration-contractile response curves in isolated rabbit aorta with pA2 of 8.14 and a slope of 1.06; shows effective antihypertensives in the model of the renal hypertensive rat.

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BIBS39 | BIBS 39

GPCR/G Protein

Angiotensin Receptor

AT2receptor

Cardiovascular Disease

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133085-33-3

524.6533

C32H36N4O3

>98% (HPLC)

DMSO: ≥ 32 mg/mL

O=C(C1=CC=CC=C1C2=CC=C(CN3C4=CC(NC(NC5CCCCC5)=O)=CC=C4N=C3CCCC)C=C2)O

[1,1'-Biphenyl]-2-carboxylic acid, 4'-[[2-butyl-6-[[(cyclohexylamino)carbonyl]amino]-1H-benzimidazol-1-yl]methyl]-

(-20℃)

With Ice Pack

≥ 2 years