Cart
sales@molnova.com
BI-D1870
CAS No. 501437-28-1
BI-D1870( BID1870 | BI D1870 | BI-D1870. )
Catalog No. M14686 CAS No. 501437-28-1
BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 125 | In Stock |
|
| 10MG | 195 | In Stock |
|
| 25MG | 318 | In Stock |
|
| 50MG | 447 | In Stock |
|
| 100MG | 624 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBI-D1870
-
NoteResearch use only, not for human use.
-
Brief DescriptionBI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively.
-
DescriptionBI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
-
In Vitro——
-
In Vivo——
-
SynonymsBID1870 | BI D1870 | BI-D1870.
-
PathwayPI3K/Akt/mTOR signaling
-
TargetS6 Kinase
-
RecptorRSK1| RSK2| RSK3| RSK4
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number501437-28-1
-
Formula Weight391.42
-
Molecular FormulaC19H23F2N5O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:78 mg/mL (199.27 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
-
SMILESO=C1N(C)C2=CN=C(NC3=CC(F)=C(O)C(F)=C3)N=C2N(CCC(C)C)C1C
-
Chemical Name2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one.
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.
molnova catalog
related products
-
PF-4708671
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays.
-
BIX 02565
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2 IC50: 1.1 nM).
-
MBM-55S
MBM-55S effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55S shows antitumor activities, and no obvious toxicity to mice.
