BI-D1870( BID1870 | BI D1870 | BI-D1870. )

Catalog No. M14686 CAS No. 501437-28-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BI-D1870
Note

Research use only, not for human use.
Brief Description

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively.
Description

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
In Vitro

——
In Vivo

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Synonyms

BID1870 | BI D1870 | BI-D1870.
Pathway

PI3K/Akt/mTOR signaling
Target

S6 Kinase
Recptor

RSK1| RSK2| RSK3| RSK4
Research Area

Cancer
Indication

——

CAS Number

501437-28-1
Formula Weight

391.42
Molecular Formula

C19H23F2N5O2
Purity

>98% (HPLC)
Solubility

DMSO:78 mg/mL (199.27 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C1N(C)C2=CN=C(NC3=CC(F)=C(O)C(F)=C3)N=C2N(CCC(C)C)C1C
Chemical Name

2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one.

1.GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

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