BI-D1870

CAS No. 501437-28-1

BI-D1870( BID1870 | BI D1870 | BI-D1870. )

Catalog No. M14686 CAS No. 501437-28-1

BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 125 In Stock
10MG 195 In Stock
25MG 318 In Stock
50MG 447 In Stock
100MG 624 In Stock
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Biological Information

  • Product Name
    BI-D1870
  • Note
    Research use only, not for human use.
  • Brief Description
    BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively.
  • Description
    BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BID1870 | BI D1870 | BI-D1870.
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    S6 Kinase
  • Recptor
    RSK1| RSK2| RSK3| RSK4
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    501437-28-1
  • Formula Weight
    391.42
  • Molecular Formula
    C19H23F2N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:78 mg/mL (199.27 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
  • SMILES
    O=C1N(C)C2=CN=C(NC3=CC(F)=C(O)C(F)=C3)N=C2N(CCC(C)C)C1C
  • Chemical Name
    2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.
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