Desmethylanethol trithione( ADT-OH | Desmethylanethol trithione | ACS1 )

Catalog No. M17391 CAS No. 18274-81-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Desmethylanethol trithione
Note

Research use only, not for human use.
Brief Description

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor.
Description

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following stroke.
In Vitro

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In Vivo

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Synonyms

ADT-OH | Desmethylanethol trithione | ACS1
Pathway

PI3K/Akt/mTOR signaling
Target

S6 Kinase
Recptor

Akt| VEGFR
Research Area

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Indication

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1. Hasegawa U,et al. Hydrolysis-Sensitive Dithiolethione Prodrug Micelles. Macromol Biosci. 2015 Nov;15(11):1512-22.

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