BI-7273 ( BI7273;BI 7273 )

Catalog No. M12926 CAS No. 1883429-21-7

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HPLC

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Product Name

BI-7273
Note

Research use only, not for human use.
Brief Description

A potent, selective and cell-permeable BRD9 bromodomain inhibitor with IC50 of 19 nM in Alpha assay.
Description

A potent, selective and cell-permeable BRD9 bromodomain inhibitor with IC50 of 19 nM in Alpha assay; displays >5-fold selectiveity over BRD7, and >5,000-fold over BRD4-BD1, BRD4-BD2, and BRD2-BD1; blocks EOL-1 cell proliferation with EC50 of 1.4 uM, and displays antitumor activity in an AML xenograft model.
Synonyms

BI7273;BI 7273
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

BRD7;BRD9
Research Area

Cancer
Indication

——

CAS Number

1883429-21-7
Formula Weight

353.41
Molecular Formula

C20H23N3O3
Purity

>98% (HPLC)
Solubility

DMSO: 10 mg/mL
SMILES

O=C1N(C)C=C(C2=CC(OC)=C(CN(C)C)C(OC)=C2)C3=CC=NC=C13
Chemical Name

2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-

1. Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75.

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