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BGB-102
CAS No. 807640-87-5
BGB-102( —— )
Catalog No. M32807 CAS No. 807640-87-5
BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 499 | Get Quote |
|
| 5MG | 777 | Get Quote |
|
| 10MG | 1026 | Get Quote |
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| 25MG | 1500 | Get Quote |
|
| 50MG | 2015 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBGB-102
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NoteResearch use only, not for human use.
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Brief DescriptionBGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders and malformations.
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DescriptionBGB-102 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.
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In VitroJNJ-26483327 (5 μM or 10 μM) with Herceptin treatment decreases HER2 phosphorylation in SKBR3 cells. JNJ-26483327 exerts greater inhibition of cell viability after 3, 6, or 8 d of treatment compared to Herceptin or JNJ-26483327 alone. JNJ-26483327 with TAPI-1 exerts less cell viability inhibition than Herceptin alone in both SKBR3 and BT474 cells.
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In VivoJNJ-26483327 (75 mg/kg, p.o.) delays xenograft tumour growth compared to vehicle treatment, but when combines with Herceptin, they can abrogate the PKB feedback loop and is synergistic in inhibition of xenograft tumour growth.
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Synonyms——
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PathwayAngiogenesis
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TargetFLT
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RecptorFLT | VEGFR | EGFR | Src
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Research Area——
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Indication——
Chemical Information
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CAS Number807640-87-5
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Formula Weight457.36
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Molecular FormulaC22H25BrN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESBrC1=CC=C2C(=C1)NC=3N=CN=C4C=C(OC)C(OCCCCCN(C)C2)=CC43
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gijsen M, et al. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol. 2010 Dec 21;8(12):e1000563.?
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