BETd-260 ( ZBC 260;ZBC260;BETd 260 )

Catalog No. M13282 CAS No. 2093388-62-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

BETd-260
Note

Research use only, not for human use.
Brief Description

BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.
Description

BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL; effectively degrades BRD4 protein at 30 pM in the RS4;11 leukemia cell line, achieves an IC50 of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors.
Synonyms

ZBC 260;ZBC260;BETd 260
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

Cancer
Indication

——

CAS Number

2093388-62-4
Formula Weight

798.91
Molecular Formula

C43H46N10O6
Purity

>98% (HPLC)
Solubility

DMSO : 25 mg/mL 31.29 mM;H2O : < 0.1 mg/mL
SMILES

O=C(N1)CCC(N(CC2=C3C=CC=C2CCCCCNC(C4=NC5=C(C(NC6=CC(C7CC7)=NN6CC)=N4)C8=CC(OC)=C(C9=C(C)ON=C9C)C=C8N5)=O)C3=O)C1=O
Chemical Name

4-((3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino)-7-(3,5-dimethylisoxazol-4-yl)-N-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide

1. Zhou B, et al. J Med Chem. 2017 Mar 24. doi: 10.1021/acs.jmedchem.6b01816.

Calculator

molnova catalog