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BDP9066

CAS No. 2226507-04-4

BDP9066( —— )

Catalog No. M33284 CAS No. 2226507-04-4

BDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BDP9066
  • Note
    Research use only, not for human use.
  • Brief Description
    BDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.
  • Description
    BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.
  • In Vitro
    BDP9066 shows antiproliferative effects with greatest activity in hematologic cancer cells. BDP9066 inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion.
  • In Vivo
    BDP9066 topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    ROCK
  • Recptor
    ROCK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2226507-04-4
  • Formula Weight
    348.44
  • Molecular Formula
    C20H24N6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (28.70 mM; Ultrasonic )
  • SMILES
    C1CC[C@@]2(CCCN(C2)c2cc[nH]c3ncc(-c4ccncn4)c23)NC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Unbekandt M, et al. Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Cancer Res. 2018 Apr 15;78(8):2096-2114.?
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    BDP9066 is a potent and selective MRCK inhibitor that inhibits MRCKβ and MRCKα/β and can be used for the prevention and treatment of skin cancer.

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