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BDP5290
CAS No. 1817698-21-7
BDP5290( —— )
Catalog No. M20658 CAS No. 1817698-21-7
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM 50 nM 10 nM and 100 nM for ROCK1 ROCK2 MRCKα and MRCKβ respectively.)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
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| 5MG | 110 | In Stock |
|
| 10MG | 178 | In Stock |
|
| 25MG | 368 | In Stock |
|
| 50MG | 536 | In Stock |
|
| 100MG | 779 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBDP5290
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NoteResearch use only, not for human use.
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Brief DescriptionBDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM 50 nM 10 nM and 100 nM for ROCK1 ROCK2 MRCKα and MRCKβ respectively.)
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DescriptionBDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM 50 nM 10 nM and 100 nM for ROCK1 ROCK2 MRCKα and MRCKβ respectively.)
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In VitroThe Ki of BDP5290 for MRCKα is 10 nM, which is slightly more than the Ki of 4 nM for MRCKβ. 3 μM BDP5290 completely inhibits myosin II light chain (MLC) phosphorylation induced by MRCKβ, but not by ROCK1 or ROCK2. At higher concentrations, BDP5290 reduces MLC phosphorylation (pMLC) to undetectable levels. BDP5290 reduces MDA-MB-231 invasion at all tested concentrations starting from 0.1 μM, with virtually complete inhibition at 10 μM. After 24 hours in the presence of BDP5290 cell viability is slightly reduced with an EC50 ?>10 μM. Wound closure is inhibited by?>60% at 1 μM BDP5290, a concentration that has no effect on cell viability.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK
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Research Area——
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Indication——
Chemical Information
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CAS Number1817698-21-7
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Formula Weight371.82
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Molecular FormulaC17H18ClN7O
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Purity>98% (HPLC)
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SolubilityDMSO:12.5 mg/mL (33.62 mM)
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SMILESClc1cn(nc1C(=O)Nc1cn[nH]c1-c1ccccn1)C1CCNCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Unbekandt M Croft D R Crighton D et al. A novel small-molecule MRCK inhibitor blocks cancer cell invasion[J]. Cell Communication and Signaling 2014 12(1):54.
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