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Gossypol

CAS No. 303-45-7

Gossypol ( BL-193 )

Catalog No. M13957 CAS No. 303-45-7

Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Gossypol
  • Note
    Research use only, not for human use.
  • Brief Description
    Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes.
  • Description
    Gossypol (BL-193) is a natural phenol that permeates cells and acts as an inhibitor for several dehydrogenase enzymes such as lactate dehydrogenase, NAD-linked enzymes; a BH3 mimetic that binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins, inhibits tumor growth in Wus1-bearing mice.
  • Synonyms
    BL-193
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    dehydrogenase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    303-45-7
  • Formula Weight
    518.55
  • Molecular Formula
    C30H30O8
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C
  • Chemical Name
    [2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lin J, et al. Oncol Rep. 2013 Aug;30(2):731-8.
2. Ciereszko A, et al. Aquat Toxicol. 2000,49(3):181-187.
3. Ferdek PE, et al. Cell Death Dis. 2017 Mar 2;8(3):e2640.
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