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BC-23
CAS No. 6298-15-3
BC-23( BC23 | NSC 45382 )
Catalog No. M15381 CAS No. 6298-15-3
BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
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| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBC-23
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NoteResearch use only, not for human use.
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Brief DescriptionBC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.
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DescriptionBC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM; dose-dependently inhibits TOP-luciferase activity in H1299 cells with IC50 of 2.3 uM; causes strong synergistic enhancement of the cancer cell death induced by low doses of radiation; effectively inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression, induces S phase and ROS generation, and overcomes radioresistance in human NSCLC cells.
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In Vitro——
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In Vivo——
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SynonymsBC23 | NSC 45382
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorBeta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number6298-15-3
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Formula Weight439.87
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Molecular FormulaC21H14ClN3O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (56.83 mM)
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SMILESO=S(C1=CC=C(NC(C2=O)=C(Cl)C(C3=C2C=CC=C3)=O)C=C1)(NC4=NC=CC=C4)=O
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Chemical Name4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]-N-pyridin-2-ylbenzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Q, et al. PLoS One. 2016 Mar 25;11(3):e0152407.
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