BAY524

Research use only, not for human use.

BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).

BAY-524 is an inhibitor of Bub1(IC50 = 450 nM.human Bub1 in the presence of 2 mM ATP).

BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC50 of 450 nM.BAY-524 (7-10 μM or 0-30 μM; 14 h or 1 h) specifically inhibit Bub1 kinase.BAY-524 (7 μM , 12 h or 7 μM, 12 μM, 3 h) affects Sgo1 and Sgo2 localization and chromatid cohesion in cells.BAY-524 (7 μM, 10 μM) affects localization and activity of the CPC.BAY-524 (7 μM, 2 h) exerts additive effect on centromere association of CPC.BAY-524 (7 μM, 48 h) marginally affects SAC signaling.BAY-524 (7 μM, 10 μM) sensitizes cells to low doses of paclitaxel. Western Blot Analysis Cell Line:hTERT-RPE1 (RPE1) and HeLa cells Concentration:7-10 μM Incubation Time:14 hResult:Drastically reduced T120 phosphorylation.Immunofluorescence Cell Line:RPE1 and HeLa cells Concentration:0-30 μM Incubation Time:1 hResult:Reduced histone H2A-T120 phosphorylation.

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Others

Other Targets

Bub1

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1445830-39-6

482.48

C24H24F2N6O3

>98% (HPLC)

DMSO:150 mg/mL?(310.89 mM;?Need ultrasonic)

CCOc1cc(F)c(Cn2nc(c(C)c2OC)-c2ncc(OC)c(Nc3ccncc3)n2)c(F)c1

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(-20℃)

With Ice Pack

≥ 2 years