BAY1217389 ( BAY1217389; BAY-1217389; BAY 1217389 )

Catalog No. M18080 CAS No. 1554458-53-5

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Product Name

BAY1217389
Note

Research use only, not for human use.
Brief Description

BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
Description

BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BAY 1217389 selectively binds to and inhibits the activity of Mps1. This inactivates the spindle assembly checkpoint (SAC), accelerates mitosis, causes chromosomal misalignment and missegregation, and mitotic checkpoint complex destabilization. This induces cell death in Mps1-overexpressing cancer cells.
Synonyms

BAY1217389; BAY-1217389; BAY 1217389
Pathway

Others
Target

Other Targets
Recptor

Mps1
Research Area

Cancer
Indication

——

CAS Number

1554458-53-5
Formula Weight

561.5
Molecular Formula

C27H24F5N5O3
Purity

98%
Solubility

DMSO : ≥ 28 mg/mL; 49.87 mM
SMILES

Cc1c(ccc(c1)c1cnc2n1nc(cc2NCCC(F)(F)F)Oc1c(c(c(cc1)OC)F)F)C(=O)NC1CC1
Chemical Name

N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide

1.Wengner AM, et al. Mol Cancer Ther. 2016 Apr;15(4):583-92.

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