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Azido-PEG4-hydrazide
CAS No. 2170240-96-5
Azido-PEG4-hydrazide( —— )
Catalog No. M33280 CAS No. 2170240-96-5
Azido-PEG4-hydrazide is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | Get Quote |
|
| 10MG | 65 | Get Quote |
|
| 25MG | 103 | Get Quote |
|
| 50MG | 150 | Get Quote |
|
| 100MG | 222 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAzido-PEG4-hydrazide
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NoteResearch use only, not for human use.
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Brief DescriptionAzido-PEG4-hydrazide is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
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DescriptionAzido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPROTACs
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Research Area——
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Indication——
Chemical Information
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CAS Number2170240-96-5
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Formula Weight305.33
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Molecular FormulaC11H23N5O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (327.51 mM; Ultrasonic )
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SMILES[N-]=[N+]=NCCOCCOCCOCCOCCC(=O)NN
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
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