Cart
sales@molnova.com
JNJ 10191584 maleate
CAS No. 869497-75-6
JNJ 10191584 maleate( JNJ 10191584 maleate salt | VUF6002 maleate )
Catalog No. M27640 CAS No. 869497-75-6
histamine H4 receptor silent antagonist
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 71 | In Stock |
|
| 5MG | 104 | In Stock |
|
| 10MG | 128 | In Stock |
|
| 25MG | 283 | In Stock |
|
| 50MG | 403 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameJNJ 10191584 maleate
-
NoteResearch use only, not for human use.
-
Brief Descriptionhistamine H4 receptor silent antagonist
-
Descriptionhistamine H4 receptor silent antagonist(In Vitro):JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM).(In Vivo):In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect.
-
In VitroJNJ10191584 maleate shows binding affinity of 26 nM and 14.1 μM to H4 and H3 receptor, respectively.JNJ10191584 maleate (3 h) shows inhibitory effects to chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively.
-
In VivoJNJ10191584 maleate (10 μg/μL; intra locus coeruleus (LC) administration; once) abolishs VUF-induced anti-allodynic effect in spared nerve injury (SNI) mice.JNJ10191584 maleate (10 μg/μL; intra LC administration; once) prevents the anti-allodynic effect of VUF 8430 in SNI mice.JNJ10191584 maleate (6 μg/mouse; intrathecal administration; pretreat once) prevents VUF 8430-induced anti-allodynic effect in SNI mice.
-
SynonymsJNJ 10191584 maleate salt | VUF6002 maleate
-
PathwayOthers
-
TargetOther Targets
-
RecptorDNA/RNA Synthesis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number869497-75-6
-
Formula Weight394.81
-
Molecular FormulaC17H19ClN4O5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESOC(=O)\C=C\C(O)=O.CN1CCN(CC1)C(=O)c1nc2ccc(Cl)cc2[nH]1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hassan AE, et al. 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases. Bioorg Chem. 2016 Apr;65:9-16.
molnova catalog
related products
-
CYM5181
CYM5181 is related to the body's immune system and can be used to study multiple sclerosis, transplant rejection, and adult respiratory distress syndrome.
-
GRL-0496
GRL-0496 is a potent inhibitor with an enzyme inhibitory activity against SARS-CoV 3CLpro with an IC50 of 30 nM and antiviral potency with an EC50 value of 6.9 μM.
-
Laurdan
Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound.
