PA-824

CAS No. 187235-37-6

PA-824 ( PA824;PA 824;Pretomanid;(S)-PA 824 )

Catalog No. M12898 CAS No. 187235-37-6

A anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid; exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 In Stock
10MG 59 In Stock
25MG 86 In Stock
50MG 112 In Stock
100MG 172 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PA-824
  • Note
    Research use only, not for human use.
  • Brief Description
    A anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid; exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL).
  • Description
    A anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid; exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL); shows potent bactericidal activity against MDR M. tuberculosis and promising oral activity in animal infection models.
  • Synonyms
    PA824;PA 824;Pretomanid;(S)-PA 824
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    tuberculosis
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    187235-37-6
  • Formula Weight
    359.26
  • Molecular Formula
    C14H12F3N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    FC(F)(F)OC1=CC=C(C=C1)CO[C@H]2CN3C(OC2)=NC([N+]([O-])=O)=C3
  • Chemical Name
    5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stover CK, et al. Nature. 2000 Jun 22;405(6789):962-6.
2. Tyagi S, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2289-93.
3. Lenaerts AJ, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2294-301.
molnova catalog
related products
  • Gatifloxacin

    A fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.

  • XF-73

    XF-73 (Exeporfinium chloride) is a novel broad-spectrum antibacterial agent that inhibits a range of gram-positive bacterial species (MIC=0.25-4 mg/mL).

  • Norvancomycin hydroc...

    An antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis.