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Avasimibe
CAS No. 166518-60-1
Avasimibe( CI-1011 | PD-148515 | CI1011 | PD148515 | CI 1011 | PD 148515 )
Catalog No. M12538 CAS No. 166518-60-1
Avasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 39 | In Stock |
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| 25MG | 74 | In Stock |
|
| 50MG | 133 | In Stock |
|
| 100MG | 237 | In Stock |
|
| 200MG | 383 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAvasimibe
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NoteResearch use only, not for human use.
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Brief DescriptionAvasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM.
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DescriptionAvasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM; potently reduces plasma cholesterol in chow-fed rats and in rabbits fed a cholesterol-free, casein-containing diet characterized by both hepatic overproduction of apo B-containing lipoproteins and delayed lipoprotein clearance; decreases both VLDL and LDL apolipoprotein B production in miniature pigs; synergistically reduces cholesteryl ester content in THP-1 macrophages combined with Atorvastatin,Dyslipidemia Phase 3 Discontinued.
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In VitroCell Viability AssayCell Line:PCa cells (PC-3 and DU 145)Concentration:0, 0.25, 5, 10, 20, 40 and 80 μMIncubation Time:1, 2, and 3 days Result:Dose dependently inhibited PC-3 and DU 145 cell viability. Western Blot Analysis Cell Line:PCa cells (PC-3 and DU 145) Concentration:10 and 20 μM Incubation Time:48 hours Result:Reduced protein levels of EMT-related proteins (β-catenin, Vimentin, N-cadherin, Snail, MMP9 and E-cadherin).Cell Cycle Analysis Cell Line:PCa cells (PC-3 and DU 145)Concentration:10 and 20 μM Incubation Time:48 hours Result:Induced G1 phase cycle arrest and altered the G1 phase-related protein levels in PCa cells.
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In VivoAnimal Model:SPF male mice (BALB/c-nude, 4 weeks old) bearing PCa cells Dosage:30 mg/kg Administration:Intraperitoneally injected for 7 weeks Result:Reduced tumour volume compared with that of the control group. Inhibited PCa growth and migration in vivo.
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SynonymsCI-1011 | PD-148515 | CI1011 | PD148515 | CI 1011 | PD 148515
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PathwayOthers
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TargetOther Targets
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RecptorACAT|CYP1A2|CYP2C19|CYP2C9
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Research AreaCardiovascular Disease
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IndicationDyslipidemia
Chemical Information
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CAS Number166518-60-1
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Formula Weight501.72102
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Molecular FormulaC29H43NO4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 28 mg/mL
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SMILESc1(C(C)C)cc(cc(c1CC(NS(Oc1c(cccc1C(C)C)C(C)C)(=O)=O)=O)C(C)C)C(C)C
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Chemical NameSulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lee HT, et al. J Med Chem. 1996 Dec 20;39(26):5031-4.
2. Ramharack R, et al. Atherosclerosis. 1998 Jan;136(1):79-87.
3. Burnett JR, et al. J Lipid Res. 1999 Jul;40(7):1317-27.
4. Llaverías G, et al. Eur J Pharmacol. 2002 Sep 6;451(1):11-7.
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