Avasimibe

Research use only, not for human use.

Avasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM.

Avasimibe (CI-1011, PD-148515) is a potent, selective inhibitor of acyl-CoA: cholesterol O-acyl transferase (ACAT) with IC50 of 60 nM; potently reduces plasma cholesterol in chow-fed rats and in rabbits fed a cholesterol-free, casein-containing diet characterized by both hepatic overproduction of apo B-containing lipoproteins and delayed lipoprotein clearance; decreases both VLDL and LDL apolipoprotein B production in miniature pigs; synergistically reduces cholesteryl ester content in THP-1 macrophages combined with Atorvastatin,Dyslipidemia Phase 3 Discontinued

CI-1011;PD-148515;CI1011;PD148515;CI 1011;PD 148515

Others

Other Targets

ACAT;CYP1A2;CYP2C19;CYP2C9

Cardiovascular Disease

Dyslipidemia

166518-60-1

501.72

C29H43NO4S

>98% (HPLC)

DMSO: ≥ 28 mg/mL

c1(C(C)C)cc(cc(c1CC(NS(Oc1c(cccc1C(C)C)C(C)C)(=O)=O)=O)C(C)C)C(C)C

Sulfamic acid, N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester

(-20℃)

With Ice Pack

≥ 2 years