Atuveciclib ( BAY 1143572;BAY1143572 )

Catalog No. M11720 CAS No. 1414943-88-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Atuveciclib
Note

Research use only, not for human use.
Brief Description

Atuveciclib (BAY-1143572) is a potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor with IC50 of 6 nM for CDK9/CyclinT1.
Description

Atuveciclib (BAY-1143572) is a potent, highly selective, orally bioavailable CDK9/P-TEFb inhibitor with IC50 of 6 nM for CDK9/CyclinT1; displays >150-fold selectivity over CDK1/2/3/5/6/7 (IC50>800 nM), also shows submicromolar inhibitory activity against GSK3α (IC50=45 nM), GSK3β (IC50=87nM); demonstrates antiproliferative activity against HeLa cells (IC50=920 nM) and MOLM‐13 cells (IC50=310 nM); exhibits anticancer activity in human AML models.Blood Cancer Phase 1 Clinical
Synonyms

BAY 1143572;BAY1143572
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Cancer
Indication

Blood cancer

CAS Number

1414943-88-6
Formula Weight

387.43
Molecular Formula

C18H18FN5O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C)(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)=N
Chemical Name

(3-((4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl)amino)benzyl)(imino)(methyl)-l6-sulfanone

1. Lücking U, et al. ChemMedChem. 2017 Nov 8;12(21):1776-1793.
2. Narita T, et al. Blood. 2017 Aug 31;130(9):1114-1124.

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