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SU-9516
CAS No. 377090-84-1
SU-9516 ( SU9516;SU 9516 )
Catalog No. M14301 CAS No. 377090-84-1
A selective CDK2 inhibitor with IC50 of 22 nM; shows less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK; decreases the phosphorylation of pRb, and increases caspase-3 activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 39 | In Stock |
|
| 5MG | 60 | In Stock |
|
| 10MG | 95 | In Stock |
|
| 25MG | 197 | In Stock |
|
| 50MG | 356 | In Stock |
|
| 100MG | 530 | In Stock |
|
| 500MG | 1152 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSU-9516
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NoteResearch use only, not for human use.
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Brief DescriptionA selective CDK2 inhibitor with IC50 of 22 nM; shows less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK; decreases the phosphorylation of pRb, and increases caspase-3 activation.
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DescriptionA selective CDK2 inhibitor with IC50 of 22 nM; shows less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK; decreases the phosphorylation of pRb, and increases caspase-3 activation.
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SynonymsSU9516;SU 9516
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1;CDK2;CDK4;p38;PKC
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number377090-84-1
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Formula Weight241.25
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Molecular FormulaC13H11N3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1NC2=C(C=C(OC)C=C2)/C1=C/C3=CN=CN3
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Chemical Name2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lane ME, et al. Cancer Res. 2001 Aug 15;61(16):6170-7.
2. Gao N, et al. Mol Pharmacol. 2006 Aug;70(2):645-55.
3. Sarathy A, et al. Mol Ther. 2017 Apr 5. pii: S1525-0016(17)30121-1.
2. Gao N, et al. Mol Pharmacol. 2006 Aug;70(2):645-55.
3. Sarathy A, et al. Mol Ther. 2017 Apr 5. pii: S1525-0016(17)30121-1.
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