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Artemisone

CAS No. 255730-18-8

Artemisone( Artemifone | BAY 44-9585 )

Catalog No. M24149 CAS No. 255730-18-8

Artemisone is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Artemisone
  • Note
    Research use only, not for human use.
  • Brief Description
    Artemisone is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.
  • Description
    Artemisone is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.
  • In Vitro
    Artemisone inhibits 3D7 and K1 P. falciparum, with IC50s of 0.88±0.59 and 1.23±0.64 nM, respectively.
  • In Vivo
    Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED50 of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration.Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS
  • Synonyms
    Artemifone | BAY 44-9585
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    CMV|P. falciparum|Parasite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    255730-18-8
  • Formula Weight
    401.52
  • Molecular Formula
    C19H31NO6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:130 mg/mL (323.77 mM; Need ultrasonic)
  • SMILES
    C[C@H](CC[C@H]1[C@H]2C)[C@H](C3)[C@]11OO[C@@]3(C)CO[C@H]1O[C@H]2N(CC1)CCS1(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59(4):658-65.
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